Anti-Biofilm Compounds From Natural Sources

Bacteria in biofilms are highly resistant against antibiotics, disinfectants and the attacks of the immune system. As a consequence, biofilm formation is often associated with chronic infections or bacterial colonisation of medical implants that are refractory to antibiotic treatment. In addition, some biofilm-related proteins as e.g. curli fibres are highly inflammatory. Anti-biofilm compounds are sought after intensively. Since living organisms are likely to protect themselves against being colonized by bacterial biofilms, one may expect to find compounds with anti-biofilm activities in plants, animals, algae or other microorganisms.